WebCyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. We hypothesized that the genetic … WebCyclophilins are a highly conserved family of peptidylprolyl cis - trans -isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA) (1,2). …
Human PPIA (Cyclophilin A) Endogenous Control …
WebSymbol Description Category UniProt ID GIFtS GC id Score; 1: PPIA: Peptidylprolyl Isomerase A: Protein Coding: P62937: 52: GC07P044811: 39.10: 2: ENSG00000230147: Peptidylpolyl Isomerase A (Cyclophilin A) (PPIA) Pseudogene Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline … See more PPIA is an 18 kDa, 165-amino acid long cytosolic protein. Like other cyclophilins, PPIA forms a β-barrel structure with a hydrophobic core. This β-barrel is composed of eight anti-parallel β-strands and capped by two … See more This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate protein folding. Generally, PPIases are found … See more • Cyclophilin • TRIM5alpha See more • Franke EK, Luban J (1995). "Cyclophilin and gag in HIV-1 replication and pathogenesis". Cell Activation and Apoptosis in HIV … See more The PPIA protein is an important apoptotic constituent. During a normal embryologic processes, or during cell injury (such as ischemia … See more Peptidylprolyl isomerase A has been shown to interact with: • ITK, • CD147, See more document signed by george washington for sale
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WebThe invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of th WebHuman Cyclophilin A (PPIA) AssayLite Antibody (APC Conjugate) DETAILS; Description: Purified antibody validated for specificity and sensitivity. Type: Polyclonal, Primary … document sign off