Phenytoin thrombocytopenia mechanism
WebOct 1, 2024 · The mechanism behind drug-induced thrombocytopenia is either a decrease in platelet production (bone marrow toxicity) or an increased destruction (immune-mediated … WebGeneric Name: phenytoin Trade Name: Dilantin Uses: Generalized tonic-clonic seizures; status epilepticus; nonepileptic seizures associated with Reye's syndrome or after head trauma; complex partial seizures Mechanism of Action: (How does it work?) May inhibit nerve impulses by limiting influx of. sodium ions across cell membrane in motor cortex
Phenytoin thrombocytopenia mechanism
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WebThrombocytopenia is a platelet count of less than 150 × 10 3 per μL and can occur from decreased platelet production, increased destruction, splenic sequestration, or dilution or … WebNov 30, 2024 · Thrombocytopenia associated with use of fiban-type platelet inhibitors seems to be caused by antibodies that recognize immunogenic conformational changes …
WebPhenytoin. Phenytoin is an effective anticonvulsant against tonic-clonic and partial seizures and an important pharmacologic tool that has increased understanding of the underlying mechanisms responsible for epileptic syndromes. From: Pharmacology and Therapeutics for Dentistry (Seventh Edition), 2024. View all Topics. Add to Mendeley.
WebJan 30, 2024 · BACKGROUND Phenytoin is an antiepileptic drug that is usually prescribed as a prevention treatment for tonic-clonic seizures or partial seizures, and as a prophylaxis … WebFeb 24, 2024 · These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. ... The mechanism by which phenytoin exerts its anticonvulsant action has not been fully elucidated however, possible contributory effects include: 1. Non-synaptic effects to …
WebDec 29, 2016 · The mechanisms contributing to thrombocytopenia in the ICU include the following: (1) pseudothrombocytopenia, (2) hemodilution, (3) platelet consumption, (4) …
Web¶ Thrombocytopenia may occur when the patient is not actively on the drug; it often responds to standard ITP therapies. Δ Quinine can also cause a thrombotic microangiopathy and/or other cytopenias. In addition to parenteral formulations, vancomycin may be present in orthopedic cement used for joint replacement. References: the new aussie slouch hatWebMechanism of Action. Phenytoin improves evidence of seizures by interfering with sodium channels in the brain, resulting in a reduction of sustained high-frequency neuronal discharges. ... These have included thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without bone marrow suppression. ... michel roussinWebFeb 17, 2024 · Phenytoin may produce falsely low results for serum concentrations of T 4 and T 3, and dexamethasone or metyrapone tests. Phenytoin may cause increased serum … the new australian dream sergio famianoWebMay 20, 2009 · This mechanism is unlikely to explain antibody binding induced by drugs such as quinine, which interact only weakly with proteins [ 14,24] and would not be … michel routenplanerWebMechanism catalyzes the binding of antithrombin III to multiple clotting factors inactivates several factors IIa (thrombin) Xa IXa XIa XIIa Clinical use immediate anticoagulation pulmonary embolism acute coronary syndrome stroke MI DVT DIC cardiovascular surgery pulmonary embolism acute coronary syndrome stroke MI DVT DIC cardiovascular surgery michel roussin/wikipediaWebThrombocytopenia following administration of phenytoin, dexamethasone and cimetidine: a case report and a potential mechanism Cimetidine and phenytoin are useful medications often used together in patients with seizure disorders secondary to brain masses or metabolic abnormalities. the new avatar icon feels mildly threateningWebMechanism of Action. ... Phenytoin Monitor serum phenytoin levels Sulfamethoxazole and trimethoprim may inhibit the hepatic metabolism of phenytoin (a CYP2C9 substrate). ... Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia ... michel roustan